Initial commit
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The MIT License (MIT)
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||||
=====================
|
||||
|
||||
**Copyright (c) 2018-2022 Anish Athalye (me@anishathalye.com)**
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|
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Permission is hereby granted, free of charge, to any person obtaining a copy of
|
||||
this software and associated documentation files (the "Software"), to deal in
|
||||
the Software without restriction, including without limitation the rights to
|
||||
use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies
|
||||
of the Software, and to permit persons to whom the Software is furnished to do
|
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so, subject to the following conditions:
|
||||
|
||||
The above copyright notice and this permission notice shall be included in all
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||||
copies or substantial portions of the Software.
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||||
|
||||
THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
|
||||
IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
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||||
FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
|
||||
AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
|
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LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
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OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
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SOFTWARE.
|
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.PHONY: main clean FORCE
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main: poster.pdf
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poster.pdf: FORCE
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latexmk -pdflatex='lualatex -interaction nonstopmode' -pdf poster.tex
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clean:
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latexmk -pdf -C
|
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% Gemini theme
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||||
% https://github.com/anishathalye/gemini
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||||
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||||
% ====================
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% Definitions
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||||
% ====================
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||||
|
||||
% Colors from https://www.cam.ac.uk/brand-resources/guidelines/typography-and-colour/rgb-and-hex-references
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\definecolor{nottblue}{HTML}{99332d}
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||||
% Extra colors
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||||
\definecolor{lightgray}{RGB}{240, 240, 240}
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||||
\definecolor{lightorange}{RGB}{255, 245, 242}
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||||
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||||
% ====================
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||||
% Theme
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||||
% ====================
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||||
|
||||
% Basic colors
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||||
\setbeamercolor{palette primary}{fg=black,bg=white}
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||||
\setbeamercolor{palette secondary}{fg=black,bg=white}
|
||||
\setbeamercolor{palette tertiary}{bg=black,fg=white}
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||||
\setbeamercolor{palette quaternary}{fg=black,bg=white}
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||||
\setbeamercolor{structure}{fg=nottblue}
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||||
|
||||
% Headline
|
||||
\setbeamercolor{headline}{fg=white,bg=nottblue}
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||||
|
||||
% Block
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||||
\setbeamercolor{block title}{fg=nottblue,bg=white}
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||||
\setbeamercolor{block separator}{bg=black}
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||||
\setbeamercolor{block body}{fg=black,bg=white}
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||||
|
||||
% Alert Block
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||||
\setbeamercolor{block alerted title}{fg=nottblue,bg=lightorange}
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||||
\setbeamercolor{block alerted separator}{bg=black}
|
||||
\setbeamercolor{block alerted body}{fg=black,bg=lightorange}
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||||
|
||||
% Example Block
|
||||
\setbeamercolor{block example title}{fg=nottblue,bg=lightgray}
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||||
\setbeamercolor{block example separator}{bg=black}
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||||
\setbeamercolor{block example body}{fg=black,bg=lightgray}
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||||
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||||
% Heading
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||||
\setbeamercolor{heading}{fg=black}
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||||
|
||||
% Itemize
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||||
\setbeamercolor{item}{fg=nottblue}
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||||
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||||
% Bibliography
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||||
\setbeamercolor{bibliography item}{fg=black}
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||||
\setbeamercolor{bibliography entry author}{fg=black}
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||||
\setbeamercolor{bibliography entry title}{fg=black}
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||||
\setbeamercolor{bibliography entry location}{fg=black}
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||||
\setbeamercolor{bibliography entry note}{fg=black}
|
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% Gemini theme
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||||
% https://github.com/anishathalye/gemini
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||||
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||||
% ====================
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||||
% Dependencies
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||||
% ====================
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||||
|
||||
\RequirePackage{exscale}
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||||
\RequirePackage{ragged2e}
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||||
\RequirePackage{changepage}
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||||
\RequirePackage{fontspec}
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||||
\RequirePackage{calc}
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||||
\RequirePackage{adjustbox}
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||||
|
||||
% ====================
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||||
% Fonts
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||||
% ====================
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||||
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||||
\newfontfamily\Raleway[Ligatures=TeX]{Raleway}
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\newfontfamily\Lato[Ligatures=TeX]{Lato}
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||||
|
||||
\usefonttheme{professionalfonts}
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||||
|
||||
\setsansfont{Lato}[
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UprightFont=*-Light,
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||||
ItalicFont=*-LightItalic,
|
||||
BoldFont=*-Regular,
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||||
BoldItalicFont=*-Italic
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||||
]
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||||
|
||||
\setbeamerfont{headline}{family=\Raleway}
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||||
\setbeamerfont{headline title}{size=\Huge,series=\bfseries}
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||||
\setbeamerfont{headline author}{size=\Large}
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||||
\setbeamerfont{headline institute}{size=\normalsize}
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||||
\setbeamerfont{block title}{family=\Raleway,size=\Large,series=\bfseries}
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||||
\setbeamerfont{heading}{family=\Lato,series=\bfseries}
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||||
\setbeamerfont{caption}{size=\small}
|
||||
\setbeamerfont{block body}{size=\large}
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||||
\setbeamerfont{footline}{family=\Raleway,size=\normalsize}
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||||
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||||
% ====================
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||||
% Macros
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||||
% ====================
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||||
|
||||
\newcommand{\samelineand}{\qquad}
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||||
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||||
% ====================
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||||
% Elements
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||||
% ====================
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||||
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||||
% List
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||||
\def\@listi{\leftmargin\leftmarginii
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||||
\topsep 1ex % spacing before
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\parsep 0\p@ \@plus\p@
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\itemsep 0.5ex} % spacing between
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||||
% Itemize
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||||
|
||||
\setbeamertemplate{itemize item}{\raise0.5ex \hbox{\vrule width 0.5ex height 0.5ex}}
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||||
\setbeamertemplate{itemize subitem}{\raise0.3ex \hbox{\vrule width 0.5ex height 0.5ex}}
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||||
\setbeamertemplate{itemize subsubitem}{\raise0.2ex \hbox{\vrule width 0.5ex height 0.5ex}}
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||||
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||||
\setbeamertemplate{itemize subitem}{\textbf{--}}
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||||
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||||
% Enumerate
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||||
|
||||
\setbeamertemplate{enumerate item}{\insertenumlabel.}
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||||
\setbeamertemplate{enumerate subitem}{\insertsubenumlabel.}
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||||
\setbeamertemplate{enumerate subsubitem}{\insertsubsubenumlabel.}
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% Equation
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||||
\setlength\belowdisplayshortskip{2ex}
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% Caption
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||||
\setbeamertemplate{caption}[numbered]
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||||
\setbeamertemplate{caption label separator}[period]
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||||
\setlength{\abovecaptionskip}{2ex}
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||||
\setlength{\belowcaptionskip}{1ex}
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||||
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||||
% Bibliography
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||||
\setbeamertemplate{bibliography item}[text]
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||||
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||||
% Navigation
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||||
\beamertemplatenavigationsymbolsempty
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||||
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||||
% ====================
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||||
% Components
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||||
% ====================
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||||
|
||||
% Heading
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||||
\newcommand\heading[1]
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||||
{%
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||||
\par\bigskip
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||||
{\usebeamerfont{heading}\usebeamercolor[fg]{heading}#1}\par\smallskip
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||||
}
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||||
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||||
% logo
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||||
\newlength{\logoleftwidth}
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||||
\setlength{\logoleftwidth}{0cm}
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\newlength{\logorightwidth}
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||||
\setlength{\logorightwidth}{0cm}
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||||
\newlength{\maxlogowidth} % space on both sides set to maxlogowidth to keep title centered
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||||
\setlength{\maxlogowidth}{0cm}
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||||
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||||
\newcommand{\logoright}[1]{
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\newcommand{\insertlogoright}{#1}
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||||
\settowidth{\logorightwidth}{\insertlogoright}
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||||
\addtolength{\logorightwidth}{10ex}
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||||
\setlength{\maxlogowidth}{\maxof{\logoleftwidth}{\logorightwidth}}
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||||
}
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||||
\newcommand{\logoleft}[1]{
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||||
\newcommand{\insertlogoleft}{#1}
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||||
\settowidth{\logoleftwidth}{\insertlogoleft}
|
||||
\addtolength{\logoleftwidth}{10ex}
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||||
\setlength{\maxlogowidth}{\maxof{\logoleftwidth}{\logorightwidth}}
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||||
}
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||||
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||||
% Headline
|
||||
\setbeamertemplate{headline}
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||||
{
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||||
\begin{beamercolorbox}{headline}
|
||||
\begin{columns}
|
||||
\begin{column}{\maxlogowidth}
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||||
\vskip5ex
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||||
\ifdefined\insertlogoleft
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||||
\vspace*{\fill}
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||||
\hspace{10ex}
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||||
\raggedright
|
||||
\insertlogoleft
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||||
\vspace*{\fill}
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||||
\else\fi
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||||
\end{column}
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||||
\begin{column}{\dimexpr\paperwidth-\maxlogowidth-\maxlogowidth}
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||||
\usebeamerfont{headline}
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||||
\vskip3ex
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||||
\centering
|
||||
\ifx \inserttitle \empty \else
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||||
{\usebeamerfont{headline title}\usebeamercolor[fg]{headline title}\inserttitle\\[0.5ex]}
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||||
\fi
|
||||
\ifx \beamer@shortauthor \empty \else
|
||||
{\usebeamerfont{headline author}\usebeamercolor[fg]{headline author}\insertauthor\\[1ex]}
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||||
\fi
|
||||
\ifx \insertinstitute \empty \else
|
||||
{\usebeamerfont{headline institute}\usebeamercolor[fg]{headline institute}\insertinstitute\\[1ex]}
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||||
\fi
|
||||
\end{column}
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||||
\begin{column}{\maxlogowidth}
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||||
\vskip5ex
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||||
\ifdefined\insertlogoright
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||||
\vspace*{\fill}
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||||
\raggedleft
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||||
\insertlogoright
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||||
\hspace{10ex}
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||||
\vspace*{\fill}
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\else\fi
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||||
\end{column}
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||||
\end{columns}
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||||
\vspace{5ex}
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||||
\ifbeamercolorempty[bg]{headline rule}{}{
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||||
\begin{beamercolorbox}[wd=\paperwidth,colsep=0.5ex]{headline rule}\end{beamercolorbox}
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||||
}
|
||||
\end{beamercolorbox}
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||||
}
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||||
|
||||
% Block
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||||
\setbeamertemplate{block begin}
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||||
{
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||||
\begin{beamercolorbox}[colsep*=0ex,dp=2ex,center]{block title}
|
||||
\vskip0pt
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||||
\usebeamerfont{block title}\insertblocktitle
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||||
\vskip-1.25ex
|
||||
\begin{beamercolorbox}[colsep=0.025ex]{block separator}\end{beamercolorbox}
|
||||
\end{beamercolorbox}
|
||||
{\parskip0pt\par}
|
||||
\usebeamerfont{block body}
|
||||
\vskip-0.5ex
|
||||
\begin{beamercolorbox}[colsep*=0ex]{block body}
|
||||
\justifying
|
||||
\setlength{\parskip}{1ex}
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||||
\vskip-2ex
|
||||
}
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||||
\setbeamertemplate{block end}
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||||
{
|
||||
\end{beamercolorbox}
|
||||
\vskip0pt
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||||
\vspace*{2ex}
|
||||
}
|
||||
|
||||
% Alert Block
|
||||
\setbeamertemplate{block alerted begin}
|
||||
{
|
||||
\begin{beamercolorbox}[colsep*=0ex,dp=2ex,center]{block alerted title}
|
||||
\vskip0pt
|
||||
\usebeamerfont{block title}\insertblocktitle
|
||||
\vskip-1.25ex
|
||||
\begin{beamercolorbox}[colsep=0.025ex]{block alerted separator}\end{beamercolorbox}
|
||||
\end{beamercolorbox}
|
||||
{\parskip0pt\par}
|
||||
\usebeamerfont{block body}
|
||||
\vskip-0.5ex
|
||||
\begin{beamercolorbox}[colsep*=0ex]{block alerted body}
|
||||
\justifying
|
||||
\begin{adjustwidth}{1ex}{1ex}
|
||||
\setlength{\parskip}{1ex}
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||||
\vskip-2ex
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||||
}
|
||||
\setbeamertemplate{block alerted end}
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||||
{
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||||
\end{adjustwidth}
|
||||
\vskip1ex
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||||
\end{beamercolorbox}
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||||
\vskip0pt
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||||
\vspace*{2ex}
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||||
}
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||||
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||||
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||||
\setbeamertemplate{block alerted begin}
|
||||
{
|
||||
\begin{beamercolorbox}[colsep*=0ex,dp=2ex,center]{block alerted title}
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||||
\vskip0pt
|
||||
\usebeamerfont{block title}\insertblocktitle
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||||
\vskip-1.25ex
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||||
\begin{beamercolorbox}[colsep=0.025ex]{block alerted separator}\end{beamercolorbox}
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||||
\end{beamercolorbox}
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||||
{\parskip0pt\par}
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||||
\usebeamerfont{block body}
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||||
\vskip-0.5ex
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||||
\begin{beamercolorbox}[colsep*=0ex]{block alerted body}
|
||||
\justifying
|
||||
\begin{adjustbox}{minipage=0.98\textwidth,margin=0pt \smallskipamount,center} \setlength{\parskip}{1ex}
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||||
\vskip 0ex
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||||
}
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||||
\setbeamertemplate{block alerted end}
|
||||
{
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||||
\end{adjustbox}
|
||||
\vskip1ex
|
||||
\end{beamercolorbox}
|
||||
\vskip0pt
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||||
\vspace*{2ex}
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||||
}
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||||
|
||||
|
||||
% Example Block
|
||||
\setbeamertemplate{block example begin}
|
||||
{
|
||||
\begin{beamercolorbox}[colsep*=0ex,dp=2ex,center]{block example title}
|
||||
\vskip0pt
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||||
\usebeamerfont{block title}\insertblocktitle
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||||
\vskip-1.25ex
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||||
\begin{beamercolorbox}[colsep=0.025ex]{block example separator}\end{beamercolorbox}
|
||||
\end{beamercolorbox}
|
||||
{\parskip0pt\par}
|
||||
\usebeamerfont{block body}
|
||||
\vskip-0.5ex
|
||||
\begin{beamercolorbox}[colsep*=0ex]{block example body}
|
||||
\justifying
|
||||
\begin{adjustbox}{minipage=0.98\textwidth,margin=0pt \smallskipamount,center} \setlength{\parskip}{1ex}
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||||
\setlength{\parskip}{1ex}
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||||
\vskip -1ex
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||||
}
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||||
\setbeamertemplate{block example end}
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||||
{
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||||
\end{adjustbox}
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||||
\vskip1ex
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||||
\end{beamercolorbox}
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||||
\vskip0pt
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||||
\vspace*{2ex}
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||||
}
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||||
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||||
% Footer
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||||
\newcommand{\footercontent}[1]{\newcommand{\insertfootercontent}{#1}}
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||||
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||||
\setbeamertemplate{footline}{
|
||||
\ifdefined\insertfootercontent
|
||||
\begin{beamercolorbox}[vmode]{headline}
|
||||
\ifbeamercolorempty[bg]{headline rule}{}{
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||||
\begin{beamercolorbox}[wd=\paperwidth,colsep=0.25ex]{headline rule}\end{beamercolorbox}
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||||
}
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||||
\vspace{1.5ex}
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||||
\hspace{\sepwidth}
|
||||
\usebeamerfont{footline}
|
||||
\centering
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||||
\insertfootercontent
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||||
\hspace{\sepwidth}
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||||
\vspace{1.5ex}
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||||
\end{beamercolorbox}
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||||
\else\fi
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||||
}
|
After Width: | Height: | Size: 5.9 KiB |
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After Width: | Height: | Size: 564 KiB |
After Width: | Height: | Size: 11 KiB |
After Width: | Height: | Size: 329 B |
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||||
% Unofficial University of Cambridge Poster Template
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||||
% https://github.com/andiac/gemini-cam
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||||
% a fork of https://github.com/anishathalye/gemini
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||||
% also refer to https://github.com/k4rtik/uchicago-poster
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||||
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||||
\documentclass[final]{beamer}
|
||||
|
||||
% ====================
|
||||
% Packages
|
||||
% ====================
|
||||
|
||||
\usepackage[T1]{fontenc}
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||||
\usepackage{lmodern}
|
||||
\usepackage[orientation=portrait,size=a0,scale=1.0]{beamerposter}
|
||||
\usetheme{gemini}
|
||||
\usecolortheme{nott}
|
||||
\usepackage{graphicx}
|
||||
\usepackage{booktabs}
|
||||
\usepackage{tikz}
|
||||
\usepackage{pgfplots}
|
||||
\pgfplotsset{compat=1.14}
|
||||
\usepackage{anyfontsize}
|
||||
\usepackage{ragged2e}
|
||||
\let\olditem\item
|
||||
\renewcommand\item{\olditem\justifying}
|
||||
|
||||
% ====================
|
||||
% Lengths
|
||||
% ====================
|
||||
\bibliographystyle{unsrt}
|
||||
% If you have N columns, choose \sepwidth and \colwidth such that
|
||||
% (N+1)*\sepwidth + N*\colwidth = \paperwidth
|
||||
\newlength{\sepwidth}
|
||||
\newlength{\colwidth}
|
||||
\setlength{\sepwidth}{0.025\paperwidth}
|
||||
\setlength{\colwidth}{0.45\paperwidth}
|
||||
|
||||
\newcommand{\separatorcolumn}{\begin{column}{\sepwidth}\end{column}}
|
||||
\setbeamertemplate{itemize/enumerate subbody begin}{\large}
|
||||
\setbeamertemplate{itemize/enumerate subsubbody begin}{\large}
|
||||
% ====================
|
||||
% Title
|
||||
% ====================
|
||||
|
||||
\title{Development and Validation of a french kidney donor marginality score}
|
||||
|
||||
\author{Corentin Choisy \inst{1} \and Magali Giral \inst{2,3} \and Etienne Dantan \inst{1}}
|
||||
|
||||
\institute[shortinst]{\inst{1} SPHERE UMR 1246, Nantes Université, Univ Tours, CHU Nantes, Inserm, Nantes, France \and \inst{2} CR2TI UMR 1064, Nantes Université, ITUN, CHU Nantes, RTRS Centaure, Nantes, France \and \inst{3} Centre d'Investigation Clinique en Biothérapie, Nantes, France}
|
||||
|
||||
% ====================
|
||||
% Footer (optional)
|
||||
% ====================
|
||||
|
||||
\footercontent{
|
||||
\href{https://www.divat.fr/}{https://www.sphere-inserm.fr/} \hfill
|
||||
Congrès Nan'thèse 2023, Nantes --- France \hfill
|
||||
\href{mailto:corentin.choisy@univ-nantes.fr}{corentin.choisy@univ-nantes.fr}}
|
||||
% (can be left out to remove footer)
|
||||
|
||||
\newcommand{\myitem}{\item[--]}
|
||||
|
||||
% ====================
|
||||
% Logo (optional)
|
||||
% ====================
|
||||
|
||||
% use this to include logos on the left and/or right side of the header:
|
||||
\logoright{\includegraphics[height=2em]{logos/transp.png}}
|
||||
\logoleft{\includegraphics[height=2em]{logos/transp.png}}
|
||||
|
||||
% ====================
|
||||
% Body
|
||||
% ====================
|
||||
|
||||
\begin{document}
|
||||
|
||||
% Refer to https://github.com/k4rtik/uchicago-poster
|
||||
% logo: https://www.cam.ac.uk/brand-resources/about-the-logo/logo-downloads
|
||||
% \addtobeamertemplate{headline}{}
|
||||
% {
|
||||
% \begin{tikzpicture}[remember picture,overlay]
|
||||
% \node [anchor=north west, inner sep=3cm] at ([xshift=-2.5cm,yshift=1.75cm]current page.north west)
|
||||
% {\includegraphics[height=7cm]{logos/unott-logo.eps}};
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% \end{tikzpicture}
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% }
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\begin{frame}[t]
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\begin{columns}[t]
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\separatorcolumn
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\begin{column}{\colwidth}
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\begin{block}{Background}
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\begin{itemize}
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\item \textbf{Kidney transplantation (KT)}: recognised as the best treatment for \textbf{end-stage chronic renal disease}
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||||
\begin{itemize}
|
||||
\setlength{\itemindent}{1em}
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||||
\item \textbf{Graft shortage} in countries with aging population
|
||||
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\textbf{\textcolor{nottblue}{$\Rightarrow$ Necessity for expansion of graft pool}}
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||||
\end{itemize}
|
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\item Wide use of \textbf{marginal grafts} with suboptimal properties for patient-graft survival
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\item Decision making tools to assist clinicians in evaluating graft proposals
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||||
\begin{itemize}
|
||||
\setlength{\itemindent}{1em}
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\item \textbf{ECD \cite{metzger2003expanded}} Older than 60 years old or between 50 and 59 with at least 2 comorbidities among: high serum creatinine, history of hypertension and death by CVA
|
||||
|
||||
\textbf{\textcolor{nottblue}{$\Rightarrow$ Binary criterion, no gradient between less and more marginal donors}}
|
||||
\item \textbf{KDRI/KDPI \cite{rao2009comprehensive}} Continuous/percentile scale defined by 10 donor features
|
||||
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||||
\textbf{\textcolor{nottblue}{$\Rightarrow$ Not adapted to the french population \cite{dantan2021covariates} and prone to increased graft refusal rate \cite{aubert2019disparities}}}
|
||||
|
||||
\end{itemize}
|
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\end{itemize}
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||||
\vskip-0.5em
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||||
|
||||
{\centering\includegraphics[scale=1.6]{Images/Chronic renal disease prevalence.pdf}\par}
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\vskip-1em
|
||||
|
||||
\end{block}
|
||||
|
||||
|
||||
|
||||
|
||||
\begin{block}{Objectives}
|
||||
|
||||
Develop and validate a \textbf{\textcolor{nottblue}{kidney donor marginality score}}, \textbf{adapted to the french population} and \textbf{suited for the current practices} in KT in France
|
||||
|
||||
\begin{itemize}
|
||||
\item \textbf{Donor/recipient interactions} will be studied in order to express donor marginality in relation to recipient characteristics
|
||||
\item \textcolor{darkgray}{\textbf{Recipient loss-of-chance} related to receiving a marginal graft as defined by the proposed score will be studied}
|
||||
\end{itemize}
|
||||
|
||||
\end{block}
|
||||
|
||||
\begin{alertblock}{Materials and Methods}
|
||||
\begin{itemize}
|
||||
\item \textbf{7622 patients} from the DIVAT national kidney transplant cohort
|
||||
\item First-time deceased donor graft recipients without donor-recipient ABO incompatibility
|
||||
\item \textbf{Multivariate Cox regression} model built via blockwise variable selection approach (Donor/Graft/Recipient features integrated/removed from the model in 11 steps)
|
||||
\item Assessment of \textbf{period/center effect} via adjusted and frailty models
|
||||
\item New variable selection steps after integration of period/center effects
|
||||
\end{itemize}
|
||||
{\centering\includegraphics[scale=0.36]{Images/analyse.png}\par}
|
||||
{\centering\small \textbf{Variable selection process} (square nodes indicate all previously included predictors were forced in the model during backward selection, circle nodes indicate no variable was forced)\par}
|
||||
|
||||
|
||||
|
||||
\end{alertblock}
|
||||
|
||||
\begin{block}{Funding}
|
||||
\centering
|
||||
This work was supported by the French Biomedicine Agency (reference: AOR Greffe 2022)
|
||||
\end{block}
|
||||
|
||||
|
||||
\vskip-0.15em
|
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\begin{block}{}
|
||||
{\centering\includegraphics[scale=0.8]{logos/logband.png}\par}
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\end{block}
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\end{column}
|
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|
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\separatorcolumn
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\begin{column}{\colwidth}
|
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|
||||
\begin{block}{Results}
|
||||
|
||||
\vskip-1em
|
||||
|
||||
\begin{figure}
|
||||
\centering
|
||||
\includegraphics[scale=1.5]{Images/km_global.pdf}
|
||||
\vskip-1.25em
|
||||
\caption{Patient/allograft survival analysis}
|
||||
\label{fig:km}
|
||||
\end{figure}
|
||||
|
||||
|
||||
|
||||
\begin{table}[]
|
||||
\centering
|
||||
\begin{tabular}{@{}lcccc@{}}
|
||||
\toprule
|
||||
& \beta & 95\% CI \\ \midrule
|
||||
Donor age & -0.020 & {[-0.037}-- {-0.003]} \\
|
||||
Donor after cardiac death & 0.691 & {[0.416}--{0.967]} \\
|
||||
Donor death by CVA & -0.616 & {[-1.224}-- {-0.008]} \\
|
||||
Donor serum creatinine & 0.001 & {[0.0001}--{0.002]} \\
|
||||
Donor height & -0.011 & {[-0.018}-- {-0.004]} \\
|
||||
Donor weight & 0.005 & {[0.001}--{0.010]} \\
|
||||
Positive donor CMV serology & 0.124 & {[0.010}--{0.239]} \\
|
||||
\addlinespace\addlinespace
|
||||
\textcolor{darkgray}{\textbf{HLA incompatibilities \geq 4}} & 0.151 & {[0.009}--{0.293]} \\
|
||||
Time on dialysis & 0.0001 & {[0.0001}--{0.0001]} \\
|
||||
Transplanted before 2012 & 0.190 & {[0.040}--{0.340]} \\
|
||||
\addlinespace\addlinespace
|
||||
Recipient age & -0.021 & {[-0.036}-- {-0.005]} \\
|
||||
Recipient BMI & 0.011 & {[-0.003}--{0.025]} \\
|
||||
Recipient history of diabetes & 0.376 & {[0.234}--{0.517]} \\
|
||||
Recipient history of cardiovascular disease & 0.408 & {[0.239}--{0.527]} \\
|
||||
Hemodialysis & 0.250 & {[0.048}--{0.452]} \\
|
||||
\textcolor{darkgray}{\textbf{Donor age*Recipient age}} & 0.001 & {[0.0001}--{0.001]} \\
|
||||
\textcolor{darkgray}{\textbf{Donor death by CVA*Recipient age}} & 0.014 & {[0.003}--{0.024]} \\ \bottomrule
|
||||
\end{tabular}
|
||||
\caption{\label{mod-table}Proportional hazards Cox model analysis of retained factors and interactions after multivariate selection}
|
||||
\end{table}
|
||||
|
||||
\vskip-1em
|
||||
|
||||
\begin{itemize}
|
||||
\item Donor age, beating heart status ($HR=2.00$), cause of death, creatininemia, height, weight and CMV serology ($HR=1.13$) will be integrated into the score. For a given donor, the score will differ depending on recipient age and donor/recipient HLA ABDR incompatibilities.
|
||||
\end{itemize}
|
||||
|
||||
\end{block}
|
||||
|
||||
\vskip-0.5em
|
||||
|
||||
\begin{exampleblock}{What's next}
|
||||
\vskip0.3em
|
||||
\begin{itemize}
|
||||
\item \textbf{Internal validation} of the model, $\frac{1}{3}$ of the database allocated to a random validation sample
|
||||
|
||||
\item \textbf{Validity assessed through:}
|
||||
\begin{itemize}
|
||||
\setlength{\itemindent}{1em}
|
||||
\item \textbf{Calibration:} calibration plot, predicted survival by score quantile, Brier score
|
||||
\item \textbf{Discrimination:} time-dependent ROC curve (AUC, PPV/NPV) and time-dependent ROC curve per recipient strata
|
||||
\end{itemize}
|
||||
\item \textbf{Propensity score}-based analysis to estimate population-averaged effects and propose a recipient loss-of-chance-based approach
|
||||
\item Development of an \textbf{online score computation tool} for clinicians
|
||||
\end{itemize}
|
||||
|
||||
\end{exampleblock}
|
||||
|
||||
\vskip-1em
|
||||
|
||||
\begin{block}{References}
|
||||
\vskip-0.15em
|
||||
\nocite{*}
|
||||
\footnotesize{\bibliographystyle{plain}\bibliography{poster}}
|
||||
|
||||
\end{block}
|
||||
|
||||
|
||||
\end{column}
|
||||
\separatorcolumn
|
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|
||||
\end{columns}
|
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\end{frame}
|
||||
|
||||
\end{document}
|