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The MIT License (MIT)
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=====================
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**Copyright (c) 2018-2022 Anish Athalye (me@anishathalye.com)**
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Permission is hereby granted, free of charge, to any person obtaining a copy of
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this software and associated documentation files (the "Software"), to deal in
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the Software without restriction, including without limitation the rights to
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use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies
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of the Software, and to permit persons to whom the Software is furnished to do
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so, subject to the following conditions:
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The above copyright notice and this permission notice shall be included in all
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copies or substantial portions of the Software.
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THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
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IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
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FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
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AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
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LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
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OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
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SOFTWARE.
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.PHONY: main clean FORCE
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main: poster.pdf
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poster.pdf: FORCE
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latexmk -pdflatex='lualatex -interaction nonstopmode' -pdf poster.tex
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clean:
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latexmk -pdf -C
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% Gemini theme
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% https://github.com/anishathalye/gemini
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% ====================
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% Definitions
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% ====================
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% Colors from https://www.cam.ac.uk/brand-resources/guidelines/typography-and-colour/rgb-and-hex-references
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\definecolor{nottblue}{HTML}{99332d}
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% Extra colors
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\definecolor{lightgray}{RGB}{240, 240, 240}
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\definecolor{lightorange}{RGB}{255, 245, 242}
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% ====================
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% Theme
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% ====================
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% Basic colors
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\setbeamercolor{palette primary}{fg=black,bg=white}
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\setbeamercolor{palette secondary}{fg=black,bg=white}
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\setbeamercolor{palette tertiary}{bg=black,fg=white}
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\setbeamercolor{palette quaternary}{fg=black,bg=white}
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\setbeamercolor{structure}{fg=nottblue}
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% Headline
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\setbeamercolor{headline}{fg=white,bg=nottblue}
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% Block
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\setbeamercolor{block title}{fg=nottblue,bg=white}
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\setbeamercolor{block separator}{bg=black}
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\setbeamercolor{block body}{fg=black,bg=white}
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% Alert Block
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\setbeamercolor{block alerted title}{fg=nottblue,bg=lightorange}
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\setbeamercolor{block alerted separator}{bg=black}
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\setbeamercolor{block alerted body}{fg=black,bg=lightorange}
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% Example Block
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\setbeamercolor{block example title}{fg=nottblue,bg=lightgray}
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\setbeamercolor{block example separator}{bg=black}
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\setbeamercolor{block example body}{fg=black,bg=lightgray}
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% Heading
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\setbeamercolor{heading}{fg=black}
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% Itemize
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\setbeamercolor{item}{fg=nottblue}
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% Bibliography
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\setbeamercolor{bibliography item}{fg=black}
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\setbeamercolor{bibliography entry author}{fg=black}
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\setbeamercolor{bibliography entry title}{fg=black}
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\setbeamercolor{bibliography entry location}{fg=black}
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\setbeamercolor{bibliography entry note}{fg=black}
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% Gemini theme
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% https://github.com/anishathalye/gemini
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% ====================
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% Dependencies
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% ====================
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\RequirePackage{exscale}
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\RequirePackage{ragged2e}
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\RequirePackage{changepage}
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\RequirePackage{fontspec}
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\RequirePackage{calc}
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\RequirePackage{adjustbox}
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% ====================
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% Fonts
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% ====================
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|
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\newfontfamily\Raleway[Ligatures=TeX]{Raleway}
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\newfontfamily\Lato[Ligatures=TeX]{Lato}
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\usefonttheme{professionalfonts}
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\setsansfont{Lato}[
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UprightFont=*-Light,
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ItalicFont=*-LightItalic,
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BoldFont=*-Regular,
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BoldItalicFont=*-Italic
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]
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\setbeamerfont{headline}{family=\Raleway}
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\setbeamerfont{headline title}{size=\Huge,series=\bfseries}
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\setbeamerfont{headline author}{size=\Large}
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\setbeamerfont{headline institute}{size=\normalsize}
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\setbeamerfont{block title}{family=\Raleway,size=\Large,series=\bfseries}
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\setbeamerfont{heading}{family=\Lato,series=\bfseries}
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\setbeamerfont{caption}{size=\small}
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\setbeamerfont{block body}{size=\large}
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\setbeamerfont{footline}{family=\Raleway,size=\normalsize}
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% ====================
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% Macros
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% ====================
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\newcommand{\samelineand}{\qquad}
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% ====================
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% Elements
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% ====================
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% List
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\def\@listi{\leftmargin\leftmarginii
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\topsep 1ex % spacing before
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\parsep 0\p@ \@plus\p@
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\itemsep 0.5ex} % spacing between
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% Itemize
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\setbeamertemplate{itemize item}{\raise0.5ex \hbox{\vrule width 0.5ex height 0.5ex}}
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\setbeamertemplate{itemize subitem}{\raise0.3ex \hbox{\vrule width 0.5ex height 0.5ex}}
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\setbeamertemplate{itemize subsubitem}{\raise0.2ex \hbox{\vrule width 0.5ex height 0.5ex}}
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\setbeamertemplate{itemize subitem}{\textbf{--}}
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% Enumerate
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\setbeamertemplate{enumerate item}{\insertenumlabel.}
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\setbeamertemplate{enumerate subitem}{\insertsubenumlabel.}
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\setbeamertemplate{enumerate subsubitem}{\insertsubsubenumlabel.}
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% Equation
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\setlength\belowdisplayshortskip{2ex}
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% Caption
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\setbeamertemplate{caption}[numbered]
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\setbeamertemplate{caption label separator}[period]
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\setlength{\abovecaptionskip}{2ex}
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\setlength{\belowcaptionskip}{1ex}
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% Bibliography
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\setbeamertemplate{bibliography item}[text]
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% Navigation
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\beamertemplatenavigationsymbolsempty
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% ====================
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||||||
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% Components
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% ====================
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% Heading
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\newcommand\heading[1]
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{%
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\par\bigskip
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{\usebeamerfont{heading}\usebeamercolor[fg]{heading}#1}\par\smallskip
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}
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% logo
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\newlength{\logoleftwidth}
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\setlength{\logoleftwidth}{0cm}
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\newlength{\logorightwidth}
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\setlength{\logorightwidth}{0cm}
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\newlength{\maxlogowidth} % space on both sides set to maxlogowidth to keep title centered
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\setlength{\maxlogowidth}{0cm}
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\newcommand{\logoright}[1]{
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\newcommand{\insertlogoright}{#1}
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\settowidth{\logorightwidth}{\insertlogoright}
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\addtolength{\logorightwidth}{10ex}
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\setlength{\maxlogowidth}{\maxof{\logoleftwidth}{\logorightwidth}}
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}
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\newcommand{\logoleft}[1]{
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\newcommand{\insertlogoleft}{#1}
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\settowidth{\logoleftwidth}{\insertlogoleft}
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\addtolength{\logoleftwidth}{10ex}
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\setlength{\maxlogowidth}{\maxof{\logoleftwidth}{\logorightwidth}}
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}
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% Headline
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\setbeamertemplate{headline}
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{
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\begin{beamercolorbox}{headline}
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\begin{columns}
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\begin{column}{\maxlogowidth}
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\vskip5ex
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\ifdefined\insertlogoleft
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\vspace*{\fill}
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\hspace{10ex}
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\raggedright
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\insertlogoleft
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\vspace*{\fill}
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\else\fi
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\end{column}
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\begin{column}{\dimexpr\paperwidth-\maxlogowidth-\maxlogowidth}
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\usebeamerfont{headline}
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\vskip3ex
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\centering
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\ifx \inserttitle \empty \else
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{\usebeamerfont{headline title}\usebeamercolor[fg]{headline title}\inserttitle\\[0.5ex]}
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\fi
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\ifx \beamer@shortauthor \empty \else
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{\usebeamerfont{headline author}\usebeamercolor[fg]{headline author}\insertauthor\\[1ex]}
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\fi
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\ifx \insertinstitute \empty \else
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{\usebeamerfont{headline institute}\usebeamercolor[fg]{headline institute}\insertinstitute\\[1ex]}
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\fi
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\end{column}
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\begin{column}{\maxlogowidth}
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\vskip5ex
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\ifdefined\insertlogoright
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\vspace*{\fill}
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\raggedleft
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\insertlogoright
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\hspace{10ex}
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\vspace*{\fill}
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\else\fi
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\end{column}
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\end{columns}
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\vspace{5ex}
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\ifbeamercolorempty[bg]{headline rule}{}{
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\begin{beamercolorbox}[wd=\paperwidth,colsep=0.5ex]{headline rule}\end{beamercolorbox}
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}
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\end{beamercolorbox}
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}
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% Block
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\setbeamertemplate{block begin}
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{
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\begin{beamercolorbox}[colsep*=0ex,dp=2ex,center]{block title}
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\vskip0pt
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\usebeamerfont{block title}\insertblocktitle
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\vskip-1.25ex
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\begin{beamercolorbox}[colsep=0.025ex]{block separator}\end{beamercolorbox}
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\end{beamercolorbox}
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{\parskip0pt\par}
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\usebeamerfont{block body}
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\vskip-0.5ex
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\begin{beamercolorbox}[colsep*=0ex]{block body}
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\justifying
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\setlength{\parskip}{1ex}
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\vskip-2ex
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}
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\setbeamertemplate{block end}
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{
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\end{beamercolorbox}
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\vskip0pt
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\vspace*{2ex}
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}
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% Alert Block
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\setbeamertemplate{block alerted begin}
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{
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\begin{beamercolorbox}[colsep*=0ex,dp=2ex,center]{block alerted title}
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\vskip0pt
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\usebeamerfont{block title}\insertblocktitle
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\vskip-1.25ex
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\begin{beamercolorbox}[colsep=0.025ex]{block alerted separator}\end{beamercolorbox}
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\end{beamercolorbox}
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{\parskip0pt\par}
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\usebeamerfont{block body}
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\vskip-0.5ex
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\begin{beamercolorbox}[colsep*=0ex]{block alerted body}
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\justifying
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\begin{adjustwidth}{1ex}{1ex}
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\setlength{\parskip}{1ex}
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\vskip-2ex
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}
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\setbeamertemplate{block alerted end}
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{
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\end{adjustwidth}
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\vskip1ex
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\end{beamercolorbox}
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\vskip0pt
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\vspace*{2ex}
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}
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\setbeamertemplate{block alerted begin}
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{
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\begin{beamercolorbox}[colsep*=0ex,dp=2ex,center]{block alerted title}
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\vskip0pt
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\usebeamerfont{block title}\insertblocktitle
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\vskip-1.25ex
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\begin{beamercolorbox}[colsep=0.025ex]{block alerted separator}\end{beamercolorbox}
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\end{beamercolorbox}
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{\parskip0pt\par}
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\usebeamerfont{block body}
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\vskip-0.5ex
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\begin{beamercolorbox}[colsep*=0ex]{block alerted body}
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\justifying
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\begin{adjustbox}{minipage=0.98\textwidth,margin=0pt \smallskipamount,center} \setlength{\parskip}{1ex}
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\vskip 0ex
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}
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\setbeamertemplate{block alerted end}
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{
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\end{adjustbox}
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\vskip1ex
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\end{beamercolorbox}
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\vskip0pt
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\vspace*{2ex}
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}
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% Example Block
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||||||
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\setbeamertemplate{block example begin}
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{
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\begin{beamercolorbox}[colsep*=0ex,dp=2ex,center]{block example title}
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\vskip0pt
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\usebeamerfont{block title}\insertblocktitle
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\vskip-1.25ex
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\begin{beamercolorbox}[colsep=0.025ex]{block example separator}\end{beamercolorbox}
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||||||
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\end{beamercolorbox}
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||||||
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{\parskip0pt\par}
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||||||
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\usebeamerfont{block body}
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\vskip-0.5ex
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\begin{beamercolorbox}[colsep*=0ex]{block example body}
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\justifying
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\begin{adjustbox}{minipage=0.98\textwidth,margin=0pt \smallskipamount,center} \setlength{\parskip}{1ex}
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\setlength{\parskip}{1ex}
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\vskip -1ex
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}
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\setbeamertemplate{block example end}
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{
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\end{adjustbox}
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||||||
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\vskip1ex
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||||||
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\end{beamercolorbox}
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\vskip0pt
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\vspace*{2ex}
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}
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% Footer
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||||||
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\newcommand{\footercontent}[1]{\newcommand{\insertfootercontent}{#1}}
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||||||
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\setbeamertemplate{footline}{
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||||||
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\ifdefined\insertfootercontent
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||||||
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\begin{beamercolorbox}[vmode]{headline}
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||||||
|
\ifbeamercolorempty[bg]{headline rule}{}{
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||||||
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\begin{beamercolorbox}[wd=\paperwidth,colsep=0.25ex]{headline rule}\end{beamercolorbox}
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||||||
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}
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||||||
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\vspace{1.5ex}
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||||||
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\hspace{\sepwidth}
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||||||
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\usebeamerfont{footline}
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|
\centering
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||||||
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\insertfootercontent
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||||||
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\hspace{\sepwidth}
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||||||
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\vspace{1.5ex}
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||||||
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\end{beamercolorbox}
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||||||
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\else\fi
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}
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After Width: | Height: | Size: 54 KiB |
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\title{Development and Validation of a french kidney donor marginality score}
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\author{Corentin Choisy \inst{1} \and Magali Giral \inst{2,3} \and Etienne Dantan \inst{1}}
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\institute[shortinst]{\inst{1} SPHERE UMR 1246, Nantes Université, Univ Tours, CHU Nantes, Inserm, Nantes, France \and \inst{2} CR2TI UMR 1064, Nantes Université, ITUN, CHU Nantes, RTRS Centaure, Nantes, France \and \inst{3} Centre d'Investigation Clinique en Biothérapie, Nantes, France}
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\href{https://www.divat.fr/}{https://www.sphere-inserm.fr/} \hfill
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Congrès Nan'thèse 2023, Nantes --- France \hfill
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\href{mailto:corentin.choisy@univ-nantes.fr}{corentin.choisy@univ-nantes.fr}}
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\begin{document}
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\begin{block}{Background}
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\begin{itemize}
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\item \textbf{Kidney transplantation (KT)}: recognised as the best treatment for \textbf{end-stage chronic renal disease}
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\begin{itemize}
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\setlength{\itemindent}{1em}
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\item \textbf{Graft shortage} in countries with aging population
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\textbf{\textcolor{nottblue}{$\Rightarrow$ Necessity for expansion of graft pool}}
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\end{itemize}
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\item Wide use of \textbf{marginal grafts} with suboptimal properties for patient-graft survival
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\item Decision making tools to assist clinicians in evaluating graft proposals
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\begin{itemize}
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\item \textbf{ECD \cite{metzger2003expanded}} Older than 60 years old or between 50 and 59 with at least 2 comorbidities among: high serum creatinine, history of hypertension and death by CVA
|
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\textbf{\textcolor{nottblue}{$\Rightarrow$ Binary criterion, no gradient between less and more marginal donors}}
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\item \textbf{KDRI/KDPI \cite{rao2009comprehensive}} Continuous/percentile scale defined by 10 donor features
|
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\textbf{\textcolor{nottblue}{$\Rightarrow$ Not adapted to the french population \cite{dantan2021covariates} and prone to increased graft refusal rate \cite{aubert2019disparities}}}
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\end{itemize}
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\vskip-0.5em
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{\centering\includegraphics[scale=1.6]{Images/Chronic renal disease prevalence.pdf}\par}
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\begin{block}{Objectives}
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Develop and validate a \textbf{\textcolor{nottblue}{kidney donor marginality score}}, \textbf{adapted to the french population} and \textbf{suited for the current practices} in KT in France
|
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||||||
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\begin{itemize}
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\item \textbf{Donor/recipient interactions} will be studied in order to express donor marginality in relation to recipient characteristics
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\item \textcolor{darkgray}{\textbf{Recipient loss-of-chance} related to receiving a marginal graft as defined by the proposed score will be studied}
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\end{itemize}
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\begin{alertblock}{Materials and Methods}
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\begin{itemize}
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\item \textbf{7622 patients} from the DIVAT national kidney transplant cohort
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\item First-time deceased donor graft recipients without donor-recipient ABO incompatibility
|
||||||
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\item \textbf{Multivariate Cox regression} model built via blockwise variable selection approach (Donor/Graft/Recipient features integrated/removed from the model in 11 steps)
|
||||||
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\item Assessment of \textbf{period/center effect} via adjusted and frailty models
|
||||||
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\item New variable selection steps after integration of period/center effects
|
||||||
|
\end{itemize}
|
||||||
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{\centering\includegraphics[scale=0.36]{Images/analyse.png}\par}
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{\centering\small \textbf{Variable selection process} (square nodes indicate all previously included predictors were forced in the model during backward selection, circle nodes indicate no variable was forced)\par}
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\end{alertblock}
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\begin{block}{Funding}
|
||||||
|
\centering
|
||||||
|
This work was supported by the French Biomedicine Agency (reference: AOR Greffe 2022)
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{\centering\includegraphics[scale=0.8]{logos/logband.png}\par}
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\begin{block}{Results}
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\vskip-1em
|
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|
\begin{figure}
|
||||||
|
\centering
|
||||||
|
\includegraphics[scale=1.5]{Images/km_global.pdf}
|
||||||
|
\vskip-1.25em
|
||||||
|
\caption{Patient/allograft survival analysis}
|
||||||
|
\label{fig:km}
|
||||||
|
\end{figure}
|
||||||
|
|
||||||
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|
||||||
|
|
||||||
|
\begin{table}[]
|
||||||
|
\centering
|
||||||
|
\begin{tabular}{@{}lcccc@{}}
|
||||||
|
\toprule
|
||||||
|
& \beta & 95\% CI \\ \midrule
|
||||||
|
Donor age & -0.020 & {[-0.037}-- {-0.003]} \\
|
||||||
|
Donor after cardiac death & 0.691 & {[0.416}--{0.967]} \\
|
||||||
|
Donor death by CVA & -0.616 & {[-1.224}-- {-0.008]} \\
|
||||||
|
Donor serum creatinine & 0.001 & {[0.0001}--{0.002]} \\
|
||||||
|
Donor height & -0.011 & {[-0.018}-- {-0.004]} \\
|
||||||
|
Donor weight & 0.005 & {[0.001}--{0.010]} \\
|
||||||
|
Positive donor CMV serology & 0.124 & {[0.010}--{0.239]} \\
|
||||||
|
\addlinespace\addlinespace
|
||||||
|
\textcolor{darkgray}{\textbf{HLA incompatibilities \geq 4}} & 0.151 & {[0.009}--{0.293]} \\
|
||||||
|
Time on dialysis & 0.0001 & {[0.0001}--{0.0001]} \\
|
||||||
|
Transplanted before 2012 & 0.190 & {[0.040}--{0.340]} \\
|
||||||
|
\addlinespace\addlinespace
|
||||||
|
Recipient age & -0.021 & {[-0.036}-- {-0.005]} \\
|
||||||
|
Recipient BMI & 0.011 & {[-0.003}--{0.025]} \\
|
||||||
|
Recipient history of diabetes & 0.376 & {[0.234}--{0.517]} \\
|
||||||
|
Recipient history of cardiovascular disease & 0.408 & {[0.239}--{0.527]} \\
|
||||||
|
Hemodialysis & 0.250 & {[0.048}--{0.452]} \\
|
||||||
|
\textcolor{darkgray}{\textbf{Donor age*Recipient age}} & 0.001 & {[0.0001}--{0.001]} \\
|
||||||
|
\textcolor{darkgray}{\textbf{Donor death by CVA*Recipient age}} & 0.014 & {[0.003}--{0.024]} \\ \bottomrule
|
||||||
|
\end{tabular}
|
||||||
|
\caption{\label{mod-table}Proportional hazards Cox model analysis of retained factors and interactions after multivariate selection}
|
||||||
|
\end{table}
|
||||||
|
|
||||||
|
\vskip-1em
|
||||||
|
|
||||||
|
\begin{itemize}
|
||||||
|
\item Donor age, beating heart status ($HR=2.00$), cause of death, creatininemia, height, weight and CMV serology ($HR=1.13$) will be integrated into the score. For a given donor, the score will differ depending on recipient age and donor/recipient HLA ABDR incompatibilities.
|
||||||
|
\end{itemize}
|
||||||
|
|
||||||
|
\end{block}
|
||||||
|
|
||||||
|
\vskip-0.5em
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||||||
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|
||||||
|
\begin{exampleblock}{What's next}
|
||||||
|
\vskip0.3em
|
||||||
|
\begin{itemize}
|
||||||
|
\item \textbf{Internal validation} of the model, $\frac{1}{3}$ of the database allocated to a random validation sample
|
||||||
|
|
||||||
|
\item \textbf{Validity assessed through:}
|
||||||
|
\begin{itemize}
|
||||||
|
\setlength{\itemindent}{1em}
|
||||||
|
\item \textbf{Calibration:} calibration plot, predicted survival by score quantile, Brier score
|
||||||
|
\item \textbf{Discrimination:} time-dependent ROC curve (AUC, PPV/NPV) and time-dependent ROC curve per recipient strata
|
||||||
|
\end{itemize}
|
||||||
|
\item \textbf{Propensity score}-based analysis to estimate population-averaged effects and propose a recipient loss-of-chance-based approach
|
||||||
|
\item Development of an \textbf{online score computation tool} for clinicians
|
||||||
|
\end{itemize}
|
||||||
|
|
||||||
|
\end{exampleblock}
|
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\vskip-1em
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\begin{block}{References}
|
||||||
|
\vskip-0.15em
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|
\nocite{*}
|
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|
\footnotesize{\bibliographystyle{plain}\bibliography{poster}}
|
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\end{document}
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Loading…
Reference in New Issue